Expression of Hand2 is sufficient for neurogenesis and cell type–specific gene expression in the enteric nervous system
نویسندگان
چکیده
منابع مشابه
Neurogenesis in the enteric nervous system.
The enteric nervous system (ENS) represents the highly organized intrinsic innervation of the gastrointestinal tract and plays a critical role for all stages of postnatal life. Severe disturbances of ENS function can significantly influence life quality or, in severe cases, can have acute life-threatening effects. Recent in vitro and in vivo studies demonstrated the persistence of neural stem c...
متن کاملEndoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.
The zebrafish enteric nervous system (ENS), like those of all other vertebrate species, is principally derived from the vagal neural crest cells (NCC). The developmental controls that govern the migration, proliferation and patterning of the ENS precursors are not well understood. We have investigated the roles of endoderm and Sonic hedgehog (SHH) in the development of the ENS. We show that end...
متن کاملPhenotypic expression in the developing murine enteric nervous system.
The development of the enteric nervous system was examined in fetal mice. Synthesis of [3H] acetylcholine ([3H]ACh) from [3H]choline and acetylcholinesterase histochemistry were used as phenotypic markers for cholinergic neurons, while the radioautographic detection of the specific uptake of [3H]serotonin (5-[3H]HT) and immunocytochemical staining with antiserum to 5-HT marked serotonergic neur...
متن کاملIon Channel Expression in the Developing Enteric Nervous System
The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ion channels, including chloride, calcium, potassium and sodium channels were already expressed by ENCCs at E11.5. There was an increase i...
متن کاملColonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System
We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. Enteric neurons and glia are present at birth in the colon of erbB2/nestin-Cre...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2006
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20989